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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD3
All Species:
16.97
Human Site:
T191
Identified Species:
31.11
UniProt:
P84022
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P84022
NP_001138574.1
425
48081
T191
Y
L
S
E
D
G
E
T
S
D
H
Q
M
N
H
Chimpanzee
Pan troglodytes
XP_001159972
710
77879
T476
Y
L
S
E
D
G
E
T
S
D
H
Q
M
N
H
Rhesus Macaque
Macaca mulatta
XP_001111262
425
48034
T191
Y
L
S
E
D
G
E
T
S
D
H
Q
M
N
H
Dog
Lupus familis
XP_866258
457
51167
E223
G
Y
I
S
E
D
G
E
T
S
D
Q
Q
L
N
Cat
Felis silvestris
Mouse
Mus musculus
Q62432
467
52248
S233
I
S
E
D
G
E
T
S
D
Q
Q
L
N
Q
S
Rat
Rattus norvegicus
O70436
467
52221
S233
I
S
E
D
G
E
T
S
D
Q
Q
L
N
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505221
437
48895
S203
I
S
E
D
G
E
T
S
D
Q
Q
L
N
Q
S
Chicken
Gallus gallus
P84023
426
48233
T192
Y
L
S
E
D
G
E
T
S
D
H
Q
M
N
P
Frog
Xenopus laevis
NP_001079320
425
48022
E191
G
Y
L
S
E
D
G
E
T
S
D
Q
M
N
H
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
S234
I
S
E
D
G
E
A
S
D
Q
Q
M
N
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
P221
Y
D
S
L
A
G
T
P
P
P
A
Y
S
P
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02330
418
47907
Q182
N
V
N
F
T
A
N
Q
F
H
Q
Y
N
P
N
Sea Urchin
Strong. purpuratus
NP_001075435
427
48320
S193
T
P
P
P
G
Y
V
S
D
D
G
E
T
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.8
99.7
85.3
N.A.
83.9
83.7
N.A.
89.9
98.8
95.7
83.3
N.A.
60
N.A.
49.6
78.6
Protein Similarity:
100
59.8
99.7
89.5
N.A.
88
88
N.A.
94.2
99.5
98.8
87.1
N.A.
73.1
N.A.
64.2
88.7
P-Site Identity:
100
100
100
6.6
N.A.
0
0
N.A.
0
93.3
26.6
0
N.A.
20
N.A.
0
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
13.3
13.3
N.A.
13.3
93.3
40
13.3
N.A.
20
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
8
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
31
31
16
0
0
39
39
16
0
0
0
0
% D
% Glu:
0
0
31
31
16
31
31
16
0
0
0
8
0
0
8
% E
% Phe:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
16
0
0
0
39
39
16
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
31
0
0
0
31
% H
% Ile:
31
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
31
8
8
0
0
0
0
0
0
0
24
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
39
0
0
% M
% Asn:
8
0
8
0
0
0
8
0
0
0
0
0
39
39
16
% N
% Pro:
0
8
8
8
0
0
0
8
8
8
0
0
0
16
8
% P
% Gln:
0
0
0
0
0
0
0
8
0
31
39
47
8
31
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
31
39
16
0
0
0
39
31
16
0
0
8
8
39
% S
% Thr:
8
0
0
0
8
0
31
31
16
0
0
0
8
0
0
% T
% Val:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
39
16
0
0
0
8
0
0
0
0
0
16
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _